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KMID : 0357419920220020105
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Korean journal of Virology
1992 Volume.22 No. 2 p.105 ~ p.110
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황규계
전복환/박호선/박송용/김경호/문홍모
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Abstract
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Varicella-zoster viruses(VZV) were isolated from the vesicles of the children of typical chicken pox in Korea. These viruses were passed many times in human embryonic lung cells and guinea pig embryonic lung cells. After having been passed many times, these viruses were tested for available biologic and biophysical markers of the attenuated strains in compared with wild strains of VZV. Infectivity ratio of the attenuated strains between guinea pig embryo lung cells and human embryo lung cells was always higher than that of wild strains. This result correlates with the passage history of the attenuated strains in guinea pig embryo lung cells. The attenuated viruses were temperature sensitive at 39C unlike the wild viruses. We, however, could not find any differences between wild strains and attenuated strains on restriction fragment length polymorphism(RFLP) pattern.
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